منابع مشابه
Microtubule-regulating kinesins
How do they reproduce? Unlike many other starfish, the general body surface of crown-of-thorns starfish is soft and flexible, which enables it to swell as it develops huge gonads. Fecundity is obviously related to size, but, as an example, a 40 cm diameter crown-of-thorns starfish may commit about 45% of its total body energy to reproduction and shed an astonishing 50 million eggs. Like many ma...
متن کاملKin I Kinesins Are Microtubule-Destabilizing Enzymes
Using in vitro assays with purified proteins, we show that XKCM1 and XKIF2, two distinct members of the internal catalytic domain (Kin I) kinesin subfamily, catalytically destabilize microtubules using a novel mechanism. Both XKCM1 and XKIF2 influence microtubule stability by targeting directly to microtubule ends where they induce a destabilizing conformational change. ATP hydrolysis recycles ...
متن کاملLateral to End-on Conversion of Chromosome-Microtubule Attachment Requires Kinesins CENP-E and MCAK
BACKGROUND Proper attachment of chromosomes to microtubules is crucial for the accurate segregation of chromosomes. Human chromosomes attach initially to lateral walls of microtubules. Subsequently, attachments to lateral walls disappear and attachments to microtubule ends (end-on attachments) predominate. While it is known in yeasts that lateral to end-on conversion of attachments occurs throu...
متن کاملAre Coiled-Coils of Dimeric Kinesins Unwound during Their Walking on Microtubule?
Dimeric kinesin motor proteins such as homodimeric kinesin-1, homodimeric Ncd and heterodimeric Kar3/Vik1are composed of two head domains which are connected together by a rod-shaped, coiled-coil stalk. Despite the extensive and intensive studies on structures, kinetics, dynamics and walking mechanism of the dimers, whether their coiled-coils are unwound or not during their walking on the micro...
متن کاملDivergent microtubule assembly rates after short- versus long-term loss of end-modulating kinesins
Depletion of microtubule (MT) regulators can initiate stable alterations in MT assembly rates that affect chromosome instability and mitotic spindle function, but the manner by which cellular MT assembly rates can stably increase or decrease is not understood. To investigate this phenomenon, we measured the response of microtubule assembly to both rapid and long-term loss of MT regulators MCAK/...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2013
ISSN: 0960-9822
DOI: 10.1016/j.cub.2013.08.012